Exhibit 99.5
TSX TRUST COMPANY
VIA ELECTRONIC TRANSMISSION
November 19, 2021
TO ALL APPLICABLE EXCHANGES AND COMMISSIONS:
| RE: | XORTX THERAPEUTICS INC |
We are pleased to confirm that copies of the following proxy-related materials were mailed on November 18, 2021 to the Registered Securityholders:
| 1 | Proxy with Notice-and-Access Notice and Request for Financial Statements |
| 2 | Proxy Return Envelope |
Yours truly,
TSX Trust Company
''Sandy Hunter''
Senior Relationship Manager
Sandy.Hunter@tmx.com
| VANCOUVER | CALGARY | TORONTO | MONTRÉAL |
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