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XORTX Pharma Corp. Announces Publication of Phase II Proof of Concept Clinical Trial in Adolescent Hypertension.

  • November 29, 2012December 22, 2020
  • by aaronbb

CALGARY- Nov 29, 2012 – XORTX Pharma Corp. wishes to congratulate Dr. Beth Soletsky and Dr Daniel Fieg on the successful completion of their phase II clinical trial in adolescent hypertension entitled “Uric Acid Reduction Rectifies Prehypertension in Obese Adolescents” and publication of results in the prestigious journal Hypertension, 2012;60:1148.

The trial, a randomized, double blind, placebo controlled study, was conducted in adolescent patients with serum uric acid (SUA) ≥ 5 mg/dL, BMI > 95th percentile and prehypertension. Increased serum uric acid is causative in early onset hypertension and a key concern in an estimated 80% of obese adolescents.   At the end of 8 weeks of treatment a clinically significant reduction of 10.1 mmHg in SBP and 8.4 mmHg in DBP were seen in patients treated with uric acid lowering agents (UALAs), compared to an increase of 1.7 mmHg and 1.6 mmHg in the placebo group (p<0.01).  Additionally, treatment with UALAs resulted in a significant decrease in systemic vascular resistance of 17.9%, compared to an 8.6% increase in placebo (p<0.05).

This important work demonstrates that lowering serum uric acid is a new, feasible therapeutic approach in the physician’s armament to treat chronically elevated serum uric acid in early stage hypertension.

Original Article: http://hyper.ahajournals.org/content/60/5/1148.abstract

About XORTX Pharma Corp. is a biopharmaceutical company dedicated to the discovery, development and commercialization of therapies that will improve patient health throughout the world. XORTX Pharma Corp. has one primary program focused on the treatment of hypertension in adolescents with accompanying hyperuricemia.  Secondary programs include uric acid lowering agents to treat insulin resistance and a diagnostic for detection of susceptibility to dermal rash and Stevens-Johnson Syndrome.

XORTX Pharma Corp. is a privately held company. For more information, please visit our web site at www.xortx.com.

Forward-Looking Statement Disclaimer
Certain statements in this press release contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 or forward-looking information under applicable Canadian securities legislation that may not be based on historical fact, including without limitation statements containing the words “believe”, “may”, “plan”, “will”, “estimate”, “continue”, “anticipate”, “intend”, “expect” and similar expressions. Such forward-looking statements or information involve known and unknown risks, uncertainties and other factors that may cause our actual results, events or developments, or industry results, to be materially different from any future results, events or developments expressed or implied by such forward-looking statements or information. Risks, uncertainties and factors that could cause such actual events or results expressed or implied by such forward-looking statements and information to differ materially from any future events or results expressed or implied by such statements and information include, but are not limited to, the risks, uncertainties and factors related to the fact that: we, together with our collaborative partners, may not be able to successfully develop all or any of our current or future products and may not be able to obtain regulatory approval in targeted indications for our current or future products in all markets; we may not achieve or maintain profitability; our future operating results are uncertain and likely to fluctuate; we may not be able to raise additional capital as and when required; we depend on our collaborative partners to perform their obligations under licensing or other collaborative agreements; we may not be successful in establishing additional corporate collaborations or licensing arrangements; we may not be able to establish marketing and sales capabilities and the costs of launching our products may be greater than anticipated; any of our products that obtain regulatory approval will be subject to extensive post-market regulation that may affect sales, marketing and profitability; any of our products that are successfully developed may not achieve market acceptance; we rely on third parties for the continued supply and manufacture of our products and have no experience in commercial manufacturing; we may face unknown risks related to intellectual property matters, including with respect to our ability to protect our intellectual property; we face increased competition from pharmaceutical and biotechnology companies; and other. Given these risks, uncertainties and factors, you are cautioned not to place undue reliance on such forward-looking statements and information, which are qualified in their entirety by this cautionary statement. All forward-looking statements and information made herein are based on our current expectations and we undertake no obligation to revise or update such forward-looking statements and information to reflect subsequent events or circumstances, except as required by law.

 

 

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XORTX Therapeutics Inc.
4000, 421 7th Avenue SW
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